Drug screening using Caco-2 monolayer film. Contrivance for efficient screening.
نویسندگان
چکیده
منابع مشابه
Improvement of paracellular transport in the Caco-2 drug screening model using protein-engineered substrates.
The Caco-2 assay has achieved wide popularity among pharmaceutical companies in the past two decades as an in vitro method for estimation of in vivo oral bioavailability of pharmaceutical compounds during preclinical characterization. Despite its popularity, this assay suffers from a severe underprediction of the transport of drugs which are absorbed paracellularly, that is, which pass through ...
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ژورنال
عنوان ژورنال: Drug Metabolism and Pharmacokinetics
سال: 1997
ISSN: 0916-1139
DOI: 10.2133/dmpk.12.543